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"Terapi reperfusi dengan IKPP pada pasien IMA-EST bertujuan menyelamatkan miokard dan menurunkan angka kematian. Kembalinya patensi arteri koroner epikardial dengan aliran TIMI derajat 3 tidak selalu berarti terjadinya aliran yang adekuat pada tingkat mikrovaskular, fenomena ini dikenal dengan istilah no reflow atau obstruksi mikrovaskular. Beberapa alat bantu diagnostik untuk mendeteksi kejadian obstuksi mikrovaskular telah banyak dikembangkan, namun sampai saat ini belum didapatkan baku emas. Mengetahui korelasi penilaian myocardial blush kuantitatif dengan program QuBE terhadap ukuran infark, fraksi ejeksi, volume akhir sistolik dan diastolik ventrikel kiri menggunakan SPECT Tc99m Tetrofosmin dalam 4-6 minggu paska IKPP pada pasien IMA-EST. Penelitian ini merupakan studi potong lintang. Gambaran angiografi pasien IMA-EST yang menjalani reperfusi dengan IKPP dari bulan Juli-Desember 2011 dievaluasi keberhasilannya mengunakan program ?QuBE?, dan pada minggu ke 4-6 paska IKPP dievaluasi dengan pemeriksaan SPECT Tc99m Tetrofosmin, untuk menilai ukuran infark, fraksi ejeksi, volume akhir sistolik dan diastolik ventrikel kiri. Dari 36 pasien didapatkan proporsi terbanyak berjenis kelamin laki-laki sebesar 94,4%, rata-rata usia pasien 54,3±7,9 tahun. Sebanyak 69,4% pasien dengan diagnosis IMA-EST anterior. Uji Spearman menunjukkan korelasi yang cukup antara nilai QuBE terhadap ukuran infark (-0,594 dan p < 0,001) dan fraksi ejeksi (r 0,531 dan P 0,001), volume akhir sistolik (r -0,496 dan P 0,002) dan volume akhir diastolik (r -0,435 dan P 0,008) ventrikel kiri. Sub analisis pada ATI LAD juga memberikan korelasi yang cukup pada keempat variabel tersebut, namun tidak pada ATI RCA. Uji multivariat parsial mengunakan kontrol variabel; usia, waktu iskemik, ATI, multivessel disease, faktor risiko PJK, kategori killip dan IMT, tetap menunjukkan nilai QuBE berkorelasi cukup dengan ukuran infark (r -0,441 dan p 0,019). Penilaian myocardial blush kuantitaif dengan program QuBE memiliki korelasi yang cukup terhadap ukuran infark, namun tidak menunjukkan korelasi terhadap fraksi ejeksi, volume akhir sistolik dan diastolik ventrikel kiri menggunakan SPECT Tc99m Tetrofosmin pada minggu ke 4-6 paska IKPP pada pasien IMAEST.

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Primary PCI as a reperfusion therapy in STEMI patients is aimed to salvage myocardium and reduce mortality. Successful restoration epicardial coronary artery patency with TIMI 3 flow has not always lead to adequate flow at microvascular level, these phenomena is known as no reflow or microvascular obstruction. Several diagnostic tools were developed to detect MVO, but until now there is no gold standard.

knowing correlation between Quantitative Myocardial blush using QuBE program with infarct size, ejection fraction, systolic and diastolic volume of the left ventricle using SPECT Tc99m Tetrofosmin at 4-6 weeks after PPCI of STEMI patients.

This study is designed as a cross sectional study. Selected angiographic result of STEMI patients that underwent primary PCI from July?December 2011 at The National Cardiac Center Harapan Kita were evaluated directly with the QuBE program. The infarct size, ejection fraction, end systolic and end diastolic volume of left ventricle were evaluated using SPECT Tc99m Tetrofosmin at 4-6 weeks after PPCI.

Thirty six consecutive patients were enrolled. Proportion of men is 94.4% and age average of 54.3±7.9 years old. Most of patients were diagnosed with anterior STEMI (69.4%). Spearmen analysis obtained a moderate correlations between QuBE score and infarct size (r -0.594, p < 0.001), left ventricle ejection fraction (r 0.531, P 0.001), end diastolic volume (r -0.496, P 0.002), end systolic volume (r -0.435, P 0.008). Sub analysis based on IRA at LAD revealed the similar result of the four variables, but not with IRA at RCA. Partial multivariate analysis adjusted with age, ischemic time, IRA, multivessel disease, CAD risk factors, Killip class and BMI consistent showed moderate correlation of QuBE score with infarct size (r -0,441, p 0.019).

Quantitative Myocardial blush using QuBE program revealed a moderate correlation with infarct size, but not with ejection fraction, systolic and diastolic volume of the left ventricle using SPECT Tc99m Tetrofosmin at 4-6 weeks after PPCI of STEMI patent."

"Penelitian ini mempunyai dua tujuan yaitu untuk mengetahui efek diet tinggi lemak dalam meningkatkan kadar kolesterol darah tikus strain Wistardan efek ekstrak Garcinia dioicadalam menurunkan kadar kolesterol darah tikus Desain penelitian yang digunakan adalah eksp erimental Hasil yang didapat menunjukkan kadar kolesterol kelompok tanpalemak tinggi lemak uji a uji b dan uji c secara berurutan adalah 71 4 g dL 73 2 g dL 28 8 g dL 28 8 dan 21 6 g dL Disimpulkan bahwa diet tinggi lemak dapat menaikkan kadar kolesterol darah tikus yang diberikan PTU tetapi tidak bermakna secara statistik serta ekstrak Garcinia dioica dap at menurunkan kadar kolesterol darah tikus yang diberikan diet tinggi lemak.

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This study has two purposes to find out the effectof high fat diet in increasing blood cholesterol Wistar rat strains andto find out the effect of Garcinia dioica extract in lowering blood cholesterol level in rats The design used in this study is experimental The findings show that the cholesterol group level of without fat of high fat of test a of test b and of test c respectively is 71 4 g dL 73 2 g dL 28 8 g dL 28 8 and 21 6 g dL Conclusions of this study are that thehigh fat diet can raise rat rsquo s blood cholesterol levels given PTU even though it is not meaningful statistically and that Garcinia dioica extract can lower rat rsquo s blood cholesterol given high fat diet."

"Studi sebelumnya telah membuktikan bahwa kanker kepaladan leher telah menjadi masalah penting di negara Asia termasuk Indonesia. Terdapat faktor resiko yang mendukung terjadinya insidens kanker tersebut dibagi menjadi faktor yang dapat dan yang tidak dapat dimodifikasi. Faktor-Faktor tersebut memiliki implikasi penting dalam mempelajari faktor resiko yang paling berpengaruh dalam insidens kanker nasofaring di Indonesia. Studi ini ditujukan untuk menentukan perbandingan antara tingkat pendidikan dan konsumsi alkohol pada pasien dengan kanker nasofaring dan kanker oral pada pasien yang datang ke klinik gigi RSCM pada tahun 2006-2009. Data dalam studi ini berdasar pada rekam medis pasien yang datang ke klinik gigi RSCM pada tahun 2006-2009. Data dianalisa menggunakan SPSS versi 20. Signifikansi di tes menggunakan Smirnof-Kolmogorov Z test. Pasien yang mengaku mengkonsumsi alkohol sebagian besar merupakan pasien dengan kanker nasofaring. Sementara, untuk tingkat pendidikan, sebagian besar pasien pada kanker nasofaring merupakan pasien dengan tingkat pendidikan yang rendah. Tidak terdapat asosiasi yang signifikan antara tingkat pendidikan dengan pasien kanker (P=0.995). Begitu pula dengan konsumsi alkohol, tidak terdapat asosiasi yang signifikan antara penggunaan alkohol pada pasien kanker nasofaring. Dapat disimpulkan bahwa tidak terdapat asosiasi antara tingkat pendidikan dan penggunaan alkohol dengan kanker nasofaring.

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As many of the previous studies has proven, head and neck cancer has been a major problem in many of Southeast Asian countries, including Indonesia. The contributing risk factors to incidence of HNC are divided into modifiable and unmodifiable risk factors. Those risk factors has very important implications in understanding the most influencing risk factors of HNC among Indonesia populationThis study aim to determine the comparison of educational level and alcohol consumption in patients with nasopharyngeal cancer and oral cancer who came to dental clinic RSCM Jakarta between 2006-2009. The data was obtained from medical record of patients diagnosed with head and neck cancer who visited oral medicine clinic of RSCM Jakarta from 2006-2009. The data then was analyzed using SPSS version 20..The significance association were tested using Kolmogorof-Smirnov Z. The result showed that patient with the presence of alcohol use were mostly diagnosed with nasopharyngeal cancer. However, after compared between nasopharyngeal and non-npc group, there were no significant association found between the two groups (P=1.000). The level of formal education also did not significantly associated with the nasopharyngeal and nonnpc (P=0.995). In conclusion, there was no significant association found between educational level and alcohol use in nasopharyngeal cancer patients."

"Riset di Bandung dan Lombok Barat tentang tindakan pencarian pengobatan pertama kali menunjukkan bahwa hanya sebanyak 30,7 % yang berobat ke Puskesmas dan 11% berobat ke dukun. Tujuan penelitian ini adalah untuk mengetahui hubungan antara faktor sosio-demografis dan tabungan kesehatan dengan pencarian pengobatan pertama kali. Metode yang digunakan ialah geographical random sampling. Dari 378 responden yang mengisi kuesioner, 63,2% memilih mengobati sendiri, 34,1% memilih berobat ke layanan kesehatan primer, dan 2,6% memilih berobat ke layanan kesehatan sekunder. Terdapat hubungan bermakna antara tingkat pendidikan (p=0,01) dan kepemilikan tabungan kesehatan (p=0,024) dengan perilaku pencarian pengobatan pertama kali.

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Studies about health seeking behavior in Bandung and Lombok Barat showed that only 30.7% go to the public health center and 11% go to Shaman. The goal of this research is to elaborate the relationship between sociodemographic factors and health saving with health seeking behavior. The method is geographical random sampling. About 63.2% respondents decide to cure the disease by themself, 34.1% go to primary health care, and 2.6% go to secondary health care. Significant result showed up between the level of education (p=0.01) and health saving (p=0.024) with health seeking behavior."

"Malaria merupakan salah satu penyakit infeksi mematikan yang disebabkan oleh parasit darah, Plasmodium sp. Setiap tahunnya lebih dari satu juta orang meninggal akibat malaria. Kematian akibat malaria terutama disebabkan oleh resistensi parasit terhadap obat antimalaria. Flamboyan (Delonix regia) telah digunakan sebagai obat tradisional terhadap malaria di Zambia, beberapa negara Afrika lain dan, Nusa Tenggara Timur. Tujuan penelitian ini adalah untuk mengetahui efektivitas antimalaria pada tikus yang diinfeksi Plasmodium berghei dan kandungan fitokima kulit batang dan biji Delonix regia. Desain penelitian yang digunakan adalah studi eksperimental. Penelitian ini menggunakan ekstrak kulit batang dan biji Delonix regia dalam tiga dosis, yaitu 2,8 mg/20 g mencit; 8,4 mg/20 g mencit; dan 14 mg/20 g mencit. Kloroquin dosis 0,52 mg/20 g mencit digunakan sebagai kontrol positif, sedangkan air digunakan sebagai kontrol negatif. Perlakuan diberikan pada hari ke-0 saat mencit dinyatakan terinfeksi Plasmodium berghei. Parasitemia diamati sebelum pemberian perlakuan (hari ke-0) dan hari ke-3. Selisih densitas parasit pada Hasil penelitian dan uji statistik dengan One Way ANOVA menunjukkan ekstrak kulit batang dan biji Delonix regia tidak memiliki efek penghambat pertumbuhan Plasmodium berghei yang bermakna jika dibandingkan dengan kontrol negatif (p>0,05).

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Malaria is one of deadly infectious disease caused by blood parasite; Plasmodium sp. Malaria caused more than one million deaths every year. Deaths caused by malaria were particularly due to the parasite's resistance to malarial drugs. Delonix regia has been used as a traditional medicine against malaria in Zambia, some of African countries, and in Nusa Tenggara Timur. This research was done to understand antimalarial effect of Delonix regia bark and seed in mice infected with Plasmodium berghei and to know their phytochemical substances.

This research used three doses of Delonix regia bark and seed, which were 2,8 mg/20 g mouse; 8,4 mg/20 g mouse; and 14 mg/20 g mouse. Chloroquine 0,52 mg/20 g mouse was used as positive control, whereas water as negative control. The treatments were given at day 0 when the mice have been proven infected by Plasmodium berghei. The observation of parasitemia conducted at day 0 before giving the treatments and day 3. The results and statistical analysis using One Way ANOVA showed Delonix regia bark and seed extract didn't show growth inhibitory effect of Plasmodium berghei compared with negative control."

"ABSTRAKPendahuluan: Sambiloto atau Andrographis panniculata merupakan sebuahtanaman herbal yang memiliki khasiat sebagai antimalaria dengan carameningkatkan kerja antioksidan dalam tubuh. Hati merupakan salah satu tempatterjadinya fase perkembangan Plasmodium pada penyakit malaria. Penelitian inibertujuan untuk menganalisis aktivitas antimalaria dari Ekstrak Etanol Sambiloto(EES) pada mencit yang diiinfeksi Plasmodium berghei secara in vivo melalupengukuran kadar MDA dan aktivitas spesifik katalase jaringan hati.Metode: Desain penelitian yang digunakan adalah eksperimental in vivomenggunakan hewan coba mencit Balb/c. Metode penelitian dilakukan denganmengelompokkan mencit ke dalam empat kelompok yaitu kelompok kontrol yangtidak diberi perlakuan, kelompok I yang diinduksi Plasmodium berghei tetapitidak diterapi, kelompok II yang diinduksi Plasmodium berghei dan diberi EES 2mg/kgBB serta kelompok III yang diinduksi Plasmodium berghei dan diberiklorokuin 10 mg/kgBB selama 3 hari. Analisis kadar MDA dilakukan denganmetode Wills dan aktivitas spesifik katalase dengan metode Mates et al.Hasil: Hasil penelitian menunjukkan terjadi penurunan kadar MDA yang tidaksignifikan pada mencit yang diinfeksi dengan Plasmodium berghei dan diberiekstrak etanol sambiloto (EES) 2 mg/kgBB dibandingkan dengan kontrol negatif(66.49 ± 22,92 vs 69.40 ± 11,69 nmol/g jaringan hati). Namun pada kelompokyang diberi perlakuan klorokuin juga terlihat penurunan kadar MDA yang tidaksignifikan dibandingkan dengan kontrol negatif (67.49 ± 7,04 vs 69.40 ± 11,69nmol/g jaringan hati). Sedangkan aktivitas spesifik katalase kelompok yang diberiEES menunjukkan peningkatan yang tidak berbeda bermakna dibandingkandengan kelompok kontrol (2,73 ± 0,59 vs 3,73 ± 1.56 Unit/mg jaringan hati).Begitupula dengan klorokuin yang menunjukkan peningkatan aktivitas spesifikkatalase yang tidak berbeda bermakna dibandingkan dengan kelompok kontrol(2,97 ± 1,53 vs 3,73 ± 1.56).Kesimpulan: Pada kelompok dengan pemberian EES 2 mg/kgBB terjadipenurunan kadar MDA serta peningkatan aktivitas spesifik katalase jaringan hatimencit dibandingkan dengan kelompok negatif, tetapi secara statistik tidakbermakna demikian pula dengan kelompok yang diberi klorokuin.

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ABSTRACTIntroduction: Andrographis panniculata or Sambiloto is a herbal plant that hasantimalarial efficacy by increasing antioxidant in body. Liver is one of the placesfor Plasmodium to develop themselves in malaria. This research aims to analyzethe activity of antimalarial from Sambiloto Ethanol Extract (SEE) in mice whichinfected by Plasmodium berghei in vivo through the measurement of MDA leveland the specific activity of catalase in liver tissue.Method: We used experimental in vivo as the reserach design, using balb/c. Theresearch design is done by grouping the mices into four groups which of theuntreated group, group I-induced by Plasmodium berghei but not treated, groupII-induced Plasmodium berghei and treated with SEE 2 mg/kg Body weight,group III-induced Plasmodium berghei and treated with chloroquine with 10mg/kg Body weight in three days. The MDA level analyze is done by the Willsmethod and the specific activity of catalase with Mates et al method.Result: The research result showed the decrease of MDA level which notsignificant in mice that is infected by Plasmodium berghei and treated by SEE 2mg/ kg BW compared to negative control (66.49 ± 22,92 vs 69.40 ± 11,69 nmol/gliver tissue). However, group that is infected by Plasmodium berghei and treatedby chloroquine also showed the decrease of MDA level which not significantcompared the negative control (67.49 ± 7,04 vs 69.40 ± 11,69 nmol/g liver tissue).Instead, group which treated by SEE showed the increase in specific activity ofcatalase compared with control (2,73 ± 0,59 vs 3,73 ± 1.56 Unit/mg liver tissue).Similarly with chloroquine group which showed an increase in specific activity ofcatalase were not significantly different compared with the control group (2.97 ±1.53 vs 3.73 ± 1.56 Unit/mg liver tissue).Conclusion: Group that treated with SEE 2 mg/kg Body weight showed decreaseof MDA level and also the increase of catalase specific activity in mice liver tissuecompared negative control, but statistically not significant as well as the groupgiven chloroquine;Introduction: Andrographis panniculata or Sambiloto is a herbal plant that hasantimalarial efficacy by increasing antioxidant in body. Liver is one of the placesfor Plasmodium to develop themselves in malaria. This research aims to analyzethe activity of antimalarial from Sambiloto Ethanol Extract (SEE) in mice whichinfected by Plasmodium berghei in vivo through the measurement of MDA leveland the specific activity of catalase in liver tissue.Method: We used experimental in vivo as the reserach design, using balb/c. Theresearch design is done by grouping the mices into four groups which of theuntreated group, group I-induced by Plasmodium berghei but not treated, groupII-induced Plasmodium berghei and treated with SEE 2 mg/kg Body weight,group III-induced Plasmodium berghei and treated with chloroquine with 10mg/kg Body weight in three days. The MDA level analyze is done by the Willsmethod and the specific activity of catalase with Mates et al method.Result: The research result showed the decrease of MDA level which notsignificant in mice that is infected by Plasmodium berghei and treated by SEE 2mg/ kg BW compared to negative control (66.49 ± 22,92 vs 69.40 ± 11,69 nmol/gliver tissue). However, group that is infected by Plasmodium berghei and treatedby chloroquine also showed the decrease of MDA level which not significantcompared the negative control (67.49 ± 7,04 vs 69.40 ± 11,69 nmol/g liver tissue).Instead, group which treated by SEE showed the increase in specific activity ofcatalase compared with control (2,73 ± 0,59 vs 3,73 ± 1.56 Unit/mg liver tissue).Similarly with chloroquine group which showed an increase in specific activity ofcatalase were not significantly different compared with the control group (2.97 ±1.53 vs 3.73 ± 1.56 Unit/mg liver tissue).Conclusion: Group that treated with SEE 2 mg/kg Body weight showed decreaseof MDA level and also the increase of catalase specific activity in mice liver tissuecompared negative control, but statistically not significant as well as the groupgiven chloroquine;Introduction: Andrographis panniculata or Sambiloto is a herbal plant that hasantimalarial efficacy by increasing antioxidant in body. Liver is one of the placesfor Plasmodium to develop themselves in malaria. This research aims to analyzethe activity of antimalarial from Sambiloto Ethanol Extract (SEE) in mice whichinfected by Plasmodium berghei in vivo through the measurement of MDA leveland the specific activity of catalase in liver tissue.Method: We used experimental in vivo as the reserach design, using balb/c. Theresearch design is done by grouping the mices into four groups which of theuntreated group, group I-induced by Plasmodium berghei but not treated, groupII-induced Plasmodium berghei and treated with SEE 2 mg/kg Body weight,group III-induced Plasmodium berghei and treated with chloroquine with 10mg/kg Body weight in three days. The MDA level analyze is done by the Willsmethod and the specific activity of catalase with Mates et al method.Result: The research result showed the decrease of MDA level which notsignificant in mice that is infected by Plasmodium berghei and treated by SEE 2mg/ kg BW compared to negative control (66.49 ± 22,92 vs 69.40 ± 11,69 nmol/gliver tissue). However, group that is infected by Plasmodium berghei and treatedby chloroquine also showed the decrease of MDA level which not significantcompared the negative control (67.49 ± 7,04 vs 69.40 ± 11,69 nmol/g liver tissue).Instead, group which treated by SEE showed the increase in specific activity ofcatalase compared with control (2,73 ± 0,59 vs 3,73 ± 1.56 Unit/mg liver tissue).Similarly with chloroquine group which showed an increase in specific activity ofcatalase were not significantly different compared with the control group (2.97 ±1.53 vs 3.73 ± 1.56 Unit/mg liver tissue).Conclusion: Group that treated with SEE 2 mg/kg Body weight showed decreaseof MDA level and also the increase of catalase specific activity in mice liver tissuecompared negative control, but statistically not significant as well as the groupgiven chloroquine"

"Salah satu fungsi ginjal adalah sebagai tempat produksi erythropoietin yang berfungsi memicu produksi sel darah merah. Pada penderita obstruksi batu ureter bilateral kronik dapat terjadi kerusakan ginjal umumnya berakibat anemia. Penelitian ini bertujuan untuk membuktikan adanya hubungan antara kadar hemoglobin dengan kadar kreatinin darah. Kadar kreatinin darah dalam penelitian ini digunakan sebagai indeks pengukuran fungsi ginjal. Penelitian dilakukan di Departemen Urologi Rumah Sakit Cipto Mangunkusumo dengan mengambil data 101 rekam medis pasien pada tahun 2009-2011 dengan batu ureter bilateral dan diambil data hemoglobin (cut-off 12 gr/dL) dan kreatinin serum (cut-off 1,5 mg/dL). Hubungan antara keduanya dihitung dengan uji chi-square dan didapatkan 70,6% pasien dengan hemoglobin rendah pada pasien dengan kadar kreatinin tinggi dan 42,0% pasien dengan hemoglobin rendah pada pasien dengan kadar kreatinin normal (p=0,004). Terdapat risiko penurunan kadar hemoglobin (OR = 3,314) pada pasien dengan kadar kreatinin yang tinggi. Disimpulkan bahwa terdapat hubungan bermakna antara kadar hemoglobin dengan kadar kreatinin darah dan pasien dengan kadar kreatinin tinggi cenderung berisiko anemia.

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One of renal function is as a place that serves erythropoietin production triggers the production of red blood cells. In patients with bilateral ureteral stone obstruction chronic kidney damage can occur generally result in anemia. This study aimed to prove the existence of a relationship between hemoglobin levels with blood creatinine levels. Blood creatinine levels in this study was used as an index of kidney function measurement. The study was conducted in the Department of Urology Hospital Cipto Mangunkusumo by retrieving 101 medical records data of patients in the years 2009-2011 with bilateral ureteral stones and data retrieving hemoglobin data (cut-off 12 g / dL) and serum creatinine (cut-off 1.5 mg / dL). Relationship between the two was calculated by chi-square test. It was found that 70.6% of patients with low hemoglobin had high creatinine levels and 42.0% of patients with low hemoglobin had normal creatinine levels (p = 0.004). These result implied that there was a risk of a decrease in hemoglobin levels (OR = 3.314) in patients with high creatinine levels. In conclusion, there was a significant relationship between level of hemoglobin and creatinine levels in blood. Patients with high creatinine levels tend to be at risk of anemia."

"Latar belakang: Bayamduri (Amaranthus spinosus L.) adalah herbal tradisional yang digunakan untuk pengobatan malaria dan belum banyak data penelitian tentang ini. Penelitian ini bertujuan untuk mengetahui aktivitas skizontisidal ekstrak air bayam duri (Amaranthus spinosus L) (EABD) terhadap mencit yang diinfeksi Plasmodium berghei secara in vivo. Metode: Mencit jantan (galur Balb/c) dengan berat 28-30 g, 7-8 minggu, dibagi menjadi 4 kelompok secara acak, tiap kelompok terdiri atas 5 ekor mencit. Kelompok K: kontrol, Kelompok A: kontrol negatif, 2 Kelompok perlakuan (B dan C). Kelompok B: ekstrak Amaranthus 120 mg/kgBB, 1 kali per hari selama 4 hari. dan kelompok C: klorokuin 10 mg/kgBB sekali sehari selama 3 hari. Seluruh perlakuan diberikan melalui oral. Hasil: Aktivitas skizontisidal darah terlihat pada semua kelompok perlakuan (B dan C), Aktivitas tertinggi terlihat pada kelompok B yaitu 91,20 ± 0,73 %, sedang kelompok C sebesar 88,92 ± 1,10 %. Kedua kelompok berbeda secara bermakna dibandingkan dengan kontrol, p≤0,05, namun kedua kelompok tidak berbeda bermakna satu sama lain, p≥0,05. Terjadi peningkatan berat badan pada kelompok EABD yang hampir sama dengan kelompok kontrol dan lebih besar dibanding kelompok klorokuin (7,6 % vs 7,05% dan 5,48%). Kesimpulan: Ekstrak air bayam duri (Amaranthus spinosus) (EABD) dosis 120 mg/kgBB menunjukkan aktivitas skizontisidal darah yang sama baik dengan pemberian klorokuin 10 mg/kgBB terhadap mencit yang diinfeksi Plasmodium berghei secara in vivo.

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Background: Amaranthus spinosus is a traditional herb used for the treatment of malaria, but the information of it?s activity still limited. The aim of this study was to determine the schizonticidal effect of a water extract of Amaranthus spinosus against Plasmodium berghei-infected mice.

Methods: Male mice (Balb/c strain) weighing 28-30 g, 7-8 weeks old, were randomly devided into 4 groups of 5 animals each. Group K: controls (nil), Group A: negative controls, and 2 treatment groups (B and C). Group B: Amaranthus 120 mg/kgBW, once per day for 4 days and group C: Chloroquine 10 mg/kgBW, once a day for 3 days. All treatments administrated orally.

Results: Blood schizonticidal activity was seen in all treatment groups, the highest activity was seen in group B ( 91.20 ± 0.73%), and group C was 88.92 ± 1.10%. Both groups were significantly different compared to control, p≤0,05), but there were no different within both group. An increase in body weight in group B are almost the same as group K and greater than group C (7.6% vs 7.05% and 5.48%).

Conclusion: The Amaranthus spinosus water extract (ASWE) at a dose 120 mg/kgBW demonstrated a good blood schizonticidal activity as well as chloroquine against Plasmodium berghei-infected mice."